Histopathologic changes in ascending aorta and risk factors related to histopathologic conditions and aortic dilatation in patients with tetralogy of Fallot

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Intrinsic histological abnormalities of aortic root and ascending aorta in tetralogy of Fallot: evidence of causative mechanism for aortic dilatation and aortopathy.

BACKGROUND Dilatation of the aortic root is a known feature in tetralogy of Fallot (TOF) patients with pulmonary stenosis (PS) or pulmonary atresia (PA). We hypothesized that intrinsic histological abnormalities of the aortic wall present since infancy are an important causative factor leading to aortic root dilatation. METHODS AND RESULTS We examined the aortic histology of 17 cases with TOF...

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Aortic root and ascending aortic dilatation in patients with repaired tetralogy of Fallot. Determinants, rates of progression, impacts on outcomes and relations to branch pulmonary artery stenosis

Materials and methods Retrospective study of 110 rtoF adults with native aorta, median age 30.9 (22.9-39.4) years were studied by cardiovascular magnetic resonance (CMR) at baseline, and at follow-up (median 6.3 [IQR:5.1-7.6] years). Aortic measurements were performed at sinus, sinotubular junction (STJ), and mid-ascending aorta level. AD was defined as diameter > 2 standard deviations larger t...

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Aortic Root and Ascending Aortic Aneurysm in an Adult with a Repaired Tetralogy of Fallot

Surgical repair of the tetralogy of Fallot is one of the most successful operations in the treatment of congenital heart diseases. We report the case of a 65-year-old man who had an aortic valve replacement at the time of complete repair of the tetralogy of Fallot at the age of forty-three. He subsequently had progressive aortic root and ascending aorta dilation to 9 cm. The aortic root and asc...

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ژورنال

عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery

سال: 2008

ISSN: 0022-5223

DOI: 10.1016/j.jtcvs.2007.06.011